Publications
2025
Li Y, Sadri Z, Blandin KJ, Narvaiz DA, Aryal UK, Lugo JN, Poolos NP, Brewster AL. Sex-specific proteomic analysis of epileptic brain tissues from Pten knockout mice and human refractory epilepsy. Exp Neurol. 2025 Jun 24;392:115361. doi: 10.1016/j.expneurol.2025.115361. [Epub ahead of print] PubMed PMID: 40571052.
Pinzon-Hoyos N, Li Y, McGee M, Poolos NP, Marchi N, Brewster AL. Drug-resistant epilepsy associated with peripheral complement decreases and sex-specific cytokine imbalances: a pilot study. Sci Rep. 2025 Feb 11;15(1):5096. doi: 10.1038/s41598-025-88654-5. PubMed PMID: 39934240; PubMed Central PMCID: PMC11814292.
Sadri Z, Brewster AL. Not All Seizures Are Created Equal: The Sex Factor in Epilepsy. Epilepsy Curr. 2025 Mar-Apr;25(2):136-138. doi: 10.1177/15357597241307855. eCollection 2025 Mar-Apr. PubMed PMID: 39780978; PubMed Central PMCID: PMC11705308.
2024
Schartz ND, Li Y, Sommer AL, Brewster AL. Acute depletion of complement C3 with cobra venom factor attenuates memory deficits induced by status epilepticus. Epilepsia Open. 2024 Dec;9(6):2173-2185. doi: 10.1002/epi4.13030. Epub 2024 Nov 5. PubMed PMID: 39501495; PubMed Central PMCID: PMC11633766.
Que Z, Olivero-Acosta MI, Robinson M, Chen I, Zhang J, Wettschurack K, Wu J, Xiao T, Otterbacher CM, Shankar V, Harlow H, Hong S, Zirkle B, Wang M, Cui N, Mandal P, Chen X, Deming B, Halurkar M, Zhao Y, Rochet JC, Xu R, Brewster AL, Wu LJ, Yuan C, Skarnes WC, Yang Y. Human iPSC-derived microglia sense and dampen hyperexcitability of cortical neurons carrying the epilepsy-associated SCN2A-L1342P mutation. J Neurosci. 2024 Nov 18;45(3). doi: 10.1523/JNEUROSCI.2027-23.2024. [Epub ahead of print] PubMed PMID: 39557580; PubMed Central PMCID: PMC11735681.
Shirani A, Saez-Calveras N, Antel JP, Yaqubi M, Moore W, Brewster AL, Stuve O. Exploring the association of disease-modifying therapies for multiple sclerosis and BTK inhibitors with epilepsy. Ther Adv Neurol Disord. 2024;17:17562864241276204. doi: 10.1177/17562864241276204. eCollection 2024. PubMed PMID: 39371642; PubMed Central PMCID: PMC11456174.
Kumari S, Brewster AL. Exploring Dendritic and Spine Structural Profiles in Epilepsy: Insights From Human Studies and Experimental Animal Models. Epilepsy Curr. 2024 Jan-Feb;24(1):40-46. doi: 10.1177/15357597231218603. eCollection 2024 Jan-Feb. PubMed PMID: 38327540; PubMed Central PMCID: PMC10846509.
Marchi N, Brewster AL. Pericytes and Microglia: Neurovascular and Immune Regulatory Cells in Seizure Disorders. 2024;. doi: 10.1093/med/9780197549469.003.0029. Review. PubMed PMID: 39637115.
2023
Schartz ND, Aroor A, Li Y, Pinzón-Hoyos N, Brewster AL. Mice deficient in complement C3 are protected against recognition memory deficits and astrogliosis induced by status epilepticus. Front Mol Neurosci. 2023;16:1265944. doi: 10.3389/fnmol.2023.1265944. eCollection 2023. PubMed PMID: 38035266; PubMed Central PMCID: PMC10682718.
Kumari S, Brewster AL. Epileptic Neurons Know JAK/STAT3. Epilepsy Curr. 2023 Sep-Oct;23(5):324-326. doi: 10.1177/15357597231181892. eCollection 2023 Sep-Oct. PubMed PMID: 37901780; PubMed Central PMCID: PMC10601025.
Aroor A, Nguyen P, Li Y, Das R, Lugo JN, Brewster AL. Assessment of tau phosphorylation and β-amyloid pathology in human drug-resistant epilepsy. Epilepsia Open. 2023 Jun;8(2):609-622. doi: 10.1002/epi4.12744. Epub 2023 Apr 24. PubMed PMID: 37052232; PubMed Central PMCID: PMC10235185.
Nguyen P, Brewster AL. Who Dunnit? Angiotensin, Inflammation, or Complement: Unresolved. Epilepsy Curr. 2023 Mar-Apr;23(2):133-135. doi: 10.1177/15357597221150057. eCollection 2023 Mar-Apr. PubMed PMID: 37122407; PubMed Central PMCID: PMC10131566.
Brewster AL. Mossy Cells and Epileptogenesis: From Synaptic Strengthening to Seizures. Epilepsy Curr. 2023 Jan-Feb;23(1):50-52. doi: 10.1177/15357597221137210. eCollection 2023 Jan-Feb. PubMed PMID: 36923346; PubMed Central PMCID: PMC10009121.
2022
Saez-Calveras N, Brewster AL, Stuve O. The validity of animal models to explore the pathogenic role of the complement system in multiple sclerosis: A review. Front Mol Neurosci. 2022;15:1017484. doi: 10.3389/fnmol.2022.1017484. eCollection 2022. Review. PubMed PMID: 36311030; PubMed Central PMCID: PMC9606595.
Brewster AL. A REST Paradox: Does it Control or Enhance Neural Activity?. Epilepsy Curr. 2022 Jun;22(3):196-197. doi: 10.1177/15357597221081582. eCollection 2022 Jun. PubMed PMID: 36474832; PubMed Central PMCID: PMC9684589.
2021
Wyatt-Johnson SK, Sommer AL, Shim KY, Brewster AL. Suppression of Microgliosis With the Colony-Stimulating Factor 1 Receptor Inhibitor PLX3397 Does Not Attenuate Memory Defects During Epileptogenesis in the Rat. Front Neurol. 2021;12:651096. doi: 10.3389/fneur.2021.651096. eCollection 2021. PubMed PMID: 34149593; PubMed Central PMCID: PMC8209304.
Aroor A, Brewster AL. Dendritic and Spine Loss in Epilepsy: What Seizures Got to Do With It?. Epilepsy Curr. 2021 May-Jun;21(3):186-188. doi: 10.1177/15357597211003096. eCollection 2021 May-Jun. PubMed PMID: 34867100; PubMed Central PMCID: PMC8609590.
Alvarado CD, Brewster AL. Hit by a Smooth CD8: T-Cell Attack on Hippocampal Neurons Triggers Limbic Encephalitis and Epilepsy. Epilepsy Curr. 2021 Oct;21(5):369-371. doi: 10.1177/15357597211030175. eCollection 2021 Oct. PubMed PMID: 34924839; PubMed Central PMCID: PMC8655268.
Brewster AL. Relationship Status Update on Astrocytic VEGFR-3 and mTOR Signaling: It's Complicated. Epilepsy Curr. 2021 Mar-Apr;21(2):117-119. doi: 10.1177/1535759720988541. eCollection 2021 Mar-Apr. PubMed PMID: 34025288; PubMed Central PMCID: PMC8010874.
2020
Aroor A, Brewster AL. Getting Excited Through Cyclin: A Role for Endothelial Cdk5 Signaling in Hippocampal Hyperexcitability. Epilepsy Curr. 2020 Nov-Dec;20(6):396-398. doi: 10.1177/1535759720958418. eCollection 2020 Nov-Dec. PubMed PMID: 34025263; PubMed Central PMCID: PMC7818198.
Reynolds CD, Nolan SO, Smith GD, Jefferson TS, Hodges SL, Brewster AL, Lugo JN. Increased expression of Fragile X mental retardation protein in malformative lesions of patients with focal cortical dysplasia. Neuroreport. 2020 Oct 7;31(14):1036-1041. doi: 10.1097/WNR.0000000000001517. PubMed PMID: 32833881; PubMed Central PMCID: PMC9621172.
Aroor A, Brewster AL. Seizing the Alzheimer's Brain: A Role for Sirtuin 3 in Hyperexcitability. Epilepsy Curr. 2020 Jul-Aug;20(4):224-226. doi: 10.1177/1535759720932157. eCollection 2020 Jul-Aug. PubMed PMID: 34025234; PubMed Central PMCID: PMC7427166.
Wyatt-Johnson SK, Brewster AL. Emerging Roles for Microglial Phagocytic Signaling in Epilepsy. Epilepsy Curr. 2020 Jan-Feb;20(1):33-38. doi: 10.1177/1535759719890336. Epub 2019 Dec 3. PubMed PMID: 31791133; PubMed Central PMCID: PMC7020537.
2019
Schartz ND, Sommer AL, Colin SA, Mendez LB, Brewster AL. Early treatment with C1 esterase inhibitor improves weight but not memory deficits in a rat model of status epilepticus. Physiol Behav. 2019 Dec 1;212:112705. doi: 10.1016/j.physbeh.2019.112705. Epub 2019 Oct 16. PubMed PMID: 31628931; PubMed Central PMCID: PMC6879103.
Brewster AL. Human Microglia Seize the Chance to be Different. Epilepsy Curr. 2019 May-Jun;19(3):190-192. doi: 10.1177/1535759719843299. Epub 2019 Apr 29. PubMed PMID: 31032668; PubMed Central PMCID: PMC6610380.
Robins MT, Blaine AT, Ha JE, Brewster AL, van Rijn RM. Repeated Use of the Psychoactive Substance Ethylphenidate Impacts Neurochemistry and Reward Learning in Adolescent Male and Female Mice. Front Neurosci. 2019;13:124. doi: 10.3389/fnins.2019.00124. eCollection 2019. PubMed PMID: 30837836; PubMed Central PMCID: PMC6389692.
2018
Schartz ND, Wyatt-Johnson SK, Price LR, Colin SA, Brewster AL. Status epilepticus triggers long-lasting activation of complement C1q-C3 signaling in the hippocampus that correlates with seizure frequency in experimental epilepsy. Neurobiol Dis. 2018 Jan;109(Pt A):163-173. doi: 10.1016/j.nbd.2017.10.012. Epub 2017 Oct 23. PubMed PMID: 29074125.
2017
Wyatt-Johnson SK, Herr SA, Brewster AL. Status Epilepticus Triggers Time-Dependent Alterations in Microglia Abundance and Morphological Phenotypes in the Hippocampus. Front Neurol. 2017;8:700. doi: 10.3389/fneur.2017.00700. eCollection 2017. PubMed PMID: 29326654; PubMed Central PMCID: PMC5741821.
Wyatt SK, Witt T, Barbaro NM, Cohen-Gadol AA, Brewster AL. Enhanced classical complement pathway activation and altered phagocytosis signaling molecules in human epilepsy. Exp Neurol. 2017 Sep;295:184-193. doi: 10.1016/j.expneurol.2017.06.009. Epub 2017 Jun 7. PubMed PMID: 28601603.
2016
Brewster AL, Marzec K, Hairston A, Ho M, Anderson AE, Lai YC. Early cardiac electrographic and molecular remodeling in a model of status epilepticus and acquired epilepsy. Epilepsia. 2016 Nov;57(11):1907-1915. doi: 10.1111/epi.13516. Epub 2016 Aug 24. PubMed PMID: 27555091; PubMed Central PMCID: PMC5545890.
Schartz ND, Herr SA, Madsen L, Butts SJ, Torres C, Mendez LB, Brewster AL. Spatiotemporal profile of Map2 and microglial changes in the hippocampal CA1 region following pilocarpine-induced status epilepticus. Sci Rep. 2016 May 4;6:24988. doi: 10.1038/srep24988. PubMed PMID: 27143585; PubMed Central PMCID: PMC4855223.
Abiega O, Beccari S, Diaz-Aparicio I, Nadjar A, Layé S, Leyrolle Q, Gómez-Nicola D, Domercq M, Pérez-Samartín A, Sánchez-Zafra V, Paris I, Valero J, Savage JC, Hui CW, Tremblay MÈ, Deudero JJ, Brewster AL, Anderson AE, Zaldumbide L, Galbarriatu L, Marinas A, Vivanco Md, Matute C, Maletic-Savatic M, Encinas JM, Sierra A. Neuronal Hyperactivity Disturbs ATP Microgradients, Impairs Microglial Motility, and Reduces Phagocytic Receptor Expression Triggering Apoptosis/Microglial Phagocytosis Uncoupling. PLoS Biol. 2016 May;14(5):e1002466. doi: 10.1371/journal.pbio.1002466. eCollection 2016 May. PubMed PMID: 27228556; PubMed Central PMCID: PMC4881984.
2001-2015: Please visit My Bibliography NCBI
