Neuroimmunology, Epilepsy, and Behavior Lab

Post-doctoral positions available!

Recruiting graduate students!

 

Brewster lab 

Epilepsy is a neurological disorder characterized by the occurrence of spontaneous recurrent seizures. In addition, epilepsy is highly co-morbid with cognitive and behavioral deficits along with catastrophic consequences such as sudden unexpected death. Unfortunately, anti-epileptic medications do not suppress seizures in one-third of the epileptic population. Therefore, our research goal is to identify potential therapeutic targets for the prevention, treatment, and control of this neurological disorder. Through our scientific discoveries we seek to help stop seizures and improve cognitive outcomes in those affected by severe epilepsy.

 

We seek to determine whether neuro-immune interactions contribute to the construction of hyperexcitable neuronal networks that may promote unprovoked seizures and cognitive deficits in epilepsy. Specifically, we aim to identify the role that microglial inflammatory and phagocytic signaling mediated by the classical complement cascade (C1q-C3), Triggering receptors expressed on myeloid cells (Trem2),  Colony stimulating factor 1 receptor (CSFR1), and the mechanistic target of Rapamycin (mTOR) molecular cascades, play in pathological synaptodendritic remodeling, seizures, and cognitive deficits in experimental models of epilepsy.

Contact Information

Amy L. Brewster, Ph.D.

Associate Professor

Department of Biological Sciences

Dedman College of Humanities & Science

Southern Methodist University

6501 Airline Rd, Dallas, TX 75205

Office: DLSB 240; Lab DLSB 215/219

Tel: 214-768-5949

albrewster@smu.edu