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Neuroimmunology, Epilepsy, and Behavior Lab

Post-doctoral positions available!

Recruiting graduate students!




My NCBI Bibliography:

Peer-reviewed work:

  1. Alvarado, C.D. and Brewster, A.L. (2021) Hit by a Smooth CD8: T-Cell Attack on Hippocampal Neurons Triggers Limbic Encephalitis and Epilepsy. Epilepsy Currents, 15357597211030175.

  2. Wyatt-Johnson, S.K., Sommer, A.L., Shim, K.Y., Brewster, A.L. (2021). Suppression of microgliosis with the colony-stimulating factor 1 receptor inhibitor PLX3397 does not attenuate memory defects during epileptogenesis in the rat. Front Neurol, 12: 651096.

  3. Aroor, A. and Brewster, AL. (2021). Dendritic and Spine Loss in Epilepsy: What Seizures Got to Do With It? Epilepsy Currents, 21 (3), 186-188.

  4. Brewster, AL. (2021). Relationship status update on astrocytic VEGFR-3 and mTOR signaling: It’s complicated. Epilepsy Currents, 21 (2), 117-119.

  5. Aroor, A. and Brewster, AL. (2020). Getting Excited Through Cyclin: A Role for Endothelial Cdk5 Signaling in Hippocampal Hyperexcitability. Epilepsy Currents, 20(6) 396-398.

  6. Reynolds, C.D., Nolan, O.S., Smith, G.D, Jefferson, T.S., Hodges, S.L., Brewster, A.L., Lugo, J.N. (2020). Increased expression of Fragile X mental retardation protein in malformative lesions of patients with focal cortical dysplasia. NeuroReport, 31(14), 1036-1041.

  7. Aroor, A. and Brewster, AL. (2020). Seizing the Alzheimer’s Brain: A Role for Sirtuin 3 in Hyperexcitability. Epilepsy Currents, 20 (4), 224-226.

  8. Wyatt-Johnson, S.K. and Brewster, A.L. (2020). Emerging roles for microglial phagocytic signaling in epilepsy. Epilepsy Currents, 20 (1), 33-38.

  9. Schartz, N.D., Sommer, A.L., Colin, S.A., Mendez-Torres, L.B., Brewster, A.L. Early treatment with C1 esterase inhibitor improves weight but not memory deficits in a rat model of status epilepticus. Physiology & Behavior, 212:112705.

  10. Brewster, A.L. (2019). Human Microglia Seize the Chance to be Different. Epilepsy Currents 19 (3), 190-192.

  11. Robins*, M.T., Blaine, A.T., Ha, E., Brewster, A.L., Van Rijn*, R.M.  (2019). Repeated Use of the Psychoactive Substance Ethylphenidate Impacts Neurochemistry and Reward Learning in Adolescent Male and Female Mice. Frontiers in Neuroscience, doi: 10.3389/fnins.2019.00124.

  12. Schartz, N.D., Wyatt-Johnson, S.K., Price, L.R., Colin, S.A., Brewster, A.L.  (2018). Status epilepticus triggers long-lasting activation of complement C1q-C3 signaling in the hippocampus that correlates with seizure frequency in experimental epilepsy. Neurobiology of Disease, 109:163-173.

  13. Wyatt-Johnson, S.K, Herr, S.A., Brewster, A.L. (2017). Status epilepticus triggers time-dependent alterations in microglia abundance and morphological phenotypes in the hippocampus. Frontiers in Neurology, 8:700.

  14. Wyatt, S.K., Witt, T., Barbaro, N.M. Cohen-Gadol, A.A., Brewster, A.L. (2017). Enhanced classical complement pathway activation and altered phagocytosis signaling molecules in human epilepsy. Experimental Neurology 295:184-193.

  15. Brewster*, A.L., MarzecUG, K., HairstonUG, A., Ho, M., Anderson, A.E., Lai, Y.C. (2016). Early electrographic and molecular remodeling in a model of status epilepticus and acquired epilepsy. Epilepsia 7(11):1907-1915.

  16. Schartz, N.D., Herr, S.A., Madsen, L., Butts, S. J., Torres, C., Mendez, L.B., Brewster, A.L.  (2016). Spatiotemporal profile of Map2 and microglial changes in the hippocampus following pilocarpine-induced status epilepticus. Scientific Reports, srep24988.

  17. Abiega, O., Becari, S., Diaz-Aparicio, I., Nadjarm, A., Layé, S., Leyrolle, Q., Gomez-Nicola, D., Domercq, M., Pérez, A., Sánchez-Zafra, V., Paris, I., Deudero, J.J.P., Brewster, A.L., Anderson, A.E., Zaldumbide, L., Galbarriatu, L., Marinas, A., Vivanco, M.dM., Matute, C., Maletic-Savatic, M., Encinas, J.M., Sierra, A. (2016). Neuronal hyperactivity disturbs ATP microgradients, impairs microglial motility, and reduces phagocytic receptor expression triggering apoptosis/microglial phagocytosis uncoupling. PLOS Biology 14(5): e1002466.

  18. Erramuzpe, A., Encinas, J.M., Sierra, A., Maletic-Savatic, M., Brewster, A.L., Anderson, A.E., Stramaglia, S., Cortes, J.M. (2015). Longitudinal variations of brain functional connectivity: A case report study based on a mouse model of epilepsy. F1000Res. 4:144.

  19. Sierra, A., S, Valcarcel-Martin, R., Pascual-Brazo, J., Aelvoet, S.A., Abiega, O., Deudero, J.J.P, Brewster, A.L., Bernales, A., Anderson, A.E., Baeckelandt, V., Maletic-Savatic, M., Encinas, J.M. (2015). Induction of reactive neural stem cells and impairment of hippocampal neurogenesis due to neuronal hyperactivity. Cell Stem Cell. 16(5):488-503.

  20. Nguyen, L.H., Brewster, A.L., Clark, M., Regnier-Golanov, A., Sunnen, N.C., Patil, V.V., Anderson, A.E. (2015). mTOR inhibition suppresses established epilepsy in the NS-Pten knockout mouse model of cortical dysplasia. Epilepsia. 56(4):636-46.

  21. Brewster, A.L., Lugo, J.N., Patil, V.V., Lee, W.L., Qian, Y., Vanegas, F., Anderson, A.E. (2013). Rapamycin reverses status epilepticus-induced memory deficits and dendritic damage. PLoS ONE 8, e57808.

  22. Marcelin, B., Lugo, J.N., Brewster, A.L., Liu Z, Lewis AS, McClelland S, Chetkovich DM, Baram TZ, Anderson AE, Becker A, Esclapez M, Bernard C. (2012). Differential dorso-ventral distributions of Kv4.2 and hyperpolarization-activated cyclic adenosine monophosphate gated channel (HCN) proteins confer distinct integrative properties to hippocampal CA1 pyramidal cell distal dendrites. Journal of Biological Chemistry, 287, 17656-17661.

  23. Surges, R., Kukley, M., Brewster, A., Rüschenschmidt, C., Schramm, J., Baram, T.Z., Beck, H., Dietrich, D. (2012). Hyperpolarization-activated cation current Ih of dentate gyrus granule cells is upregulated in human and rat temporal lobe epilepsy. Biochemical and Biophysical Research Communications, 420, 156-160.

  24. Lugo, J.N., Brewster, A.L., Spencer, C.M., Anderson, A.E. (2012). Kv4.2 knockout mice have hippocampal-dependent learning and memory deficits. Learning and Memory, 19,182-189.

  25. Sunnen, C.N., Brewster, A.L., Lugo, J.N., Vanegas, F., Turcios, E., Mukhi, S., Parghi, D., D'Arcangelo, G., Anderson, A.E. (2011). mTORC1 inhibition prevents epileptogenesis and reverses mossy fiber sprouting in NS-Pten knockout mice. Epilepsia, 52, 2065-2075.

  26. Dubé, C.M., McClelland, S., Choy, M.K., Brewster, A.L., Noam, Y., Baram, T.Z. (2010). Fever, febrile seizures, and epileptogenesis. Epilepsia, 51 (s5), 33-33.

  27. Bealer, S.L., Little, J.G., Metcalf, C.S., Brewster, A.L., Anderson, A.E. (2010). Autonomic and Cellular mechanisms mediating detrimental cardiac effects of status epilepticus. Epilepsy Research, 91, 66-73.

  28. Dubé, C.M., Brewster, A.L., Baram, T.Z. (2009). Febrile seizures: Mechanisms and relationship to epilepsy. Brain and Development, 31, 366-371.

  29. Kanyshkova, T., Pawlowski, M., Meuth, P., Bender, R., Brewster, A.L., Baumann, A., Dubé C.M., Baram, T.Z., Pape, H.C., Budde, T. (2009). Postnatal expression patterns of HCN channel isoforms in thalamic neurons: relationship to maturation of thalamocortical oscillations. Journal of Neuroscience, 29, 8847-8857.

  30. Zha, Q.Q., Brewster, A.L., Richichi, C., Baram, T.Z. (2008). Activity-dependent heteromerization of the Hyperpolarization-activated, cyclic nucleotide gated (HCN) channels: role of N-linked glycosylation. Journal of Neurochemistry, 105, 68-77.

  31. Richichi, C., Brewster, A.L., Bender, R.A., Simeone, T.A., Zha, Q.Q., Yin, H.Z., Weiss, J.H., Baram, T.Z. (2008). Mechanisms of seizure-induced 'transcriptional channelopathy' of hyperpolarization-activated cyclic nucleotide gated (HCN) channels. Neurobiology of Disease, 29, 297-305.

  32. Bender, R.A., Kirschstein, T., Kretz, O., Brewster, A.L., Richichi, C., Rüschenschmidt, C., Shigemoto, R., Beck, H., Frotscher, M., Baram, T.Z. (2007). Localization of HCN1 channels to presynaptic compartments: novel plasticity that may contribute to hippocampal maturation. Journal of Neuroscience, 27, 4697-4706.

  33. Brewster*, A.L., Chen*, Y., Bender, R.A., Yeh, A., Shigemoto, R., Baram, T.Z. (2007). Quantitative analysis and subcellular distribution of mRNA and protein expression of the hyperpolarization-activated cyclic nucleotide-gated (HCN) channels throughout development in rat hippocampus. Cerebral Cortex, 17, 702-712.

  34. Dubé, C.M., Brewster, A.L., Richichi, C., Zha, Q., Baram, T.Z. (2007). Fever, febrile seizures and epilepsy. Trends in Neuroscience, 30, 490-496.

  35. Kuisle*, M., Wanaverbecq*, N.J., Brewster*, A.L., Frere, S.A., Pinault, D., Baram, T.Z., Lüthi, A. (2006). Functional stabilization of weakened thalamic pacemaker channel regulation in absence epilepsy. Journal of Physiology, 575, 83-100. *Authors contributed equally

  36. Surges, R., Brewster, A.L., Bender, R.A., Beck, H., Feuerstein, T.J., Baram, T.Z. (2006). Regulated expression of HCN channels and cAMP levels shape the properties of the h current in developing rat hippocampus. European Journal of Neuroscience, 24, 94-104.

  37. Brewster, A.L., Bernard, J.A., Gall, C.M., Baram, T.Z. (2005). Formation of heteromeric hyperpolarization-activated cyclic nucleotide-gated (HCN) channels in the hippocampus is regulated by developmental seizures. Neurobiology of Disease, 19, 200-207.

  38. Bender, R.A., Soleymani, S.V., Brewster, A.L., Nguyen, S.T., Beck, H., Mathern, G.W., Baram, T.Z. (2003). Enhanced expression of a specific hyperpolarization-activated cyclic nucleotide-gated cation channel (HCN) in surviving dentate gyrus granule cells of human and experimental epileptic hippocampus. Journal of Neuroscience, 23, 6826-6836.

  39. Brewster, A.L., Bender, R.A., Chen, Y., Dubé, C., Eghbal-Ahmadi, M., Baram, T.Z. (2002). Developmental febrile seizures modulate hippocampal gene expression of hyperpolarization-activated channels in an isoform and cell-specific manner. Journal of Neuroscience, 22, 4591-4599.

  40. Bender*, R.A., Brewster*, A.L., Santoro, B., Ludwig, A., Hofmann, F., Biel, M., Baram, T.Z. (2001). Differential and age-dependent expression of hyperpolarization-activated, cyclic nucleotide-gated cation channel isoforms 1-4 suggest evolving roles in the developing rat hippocampus. Neuroscience, 106, 689-698. *Authors contributed equally

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